Last updated: 03/04/2013
Closing date: 03/04/2014
Emergence of continuous flow chemistry on laboratory scale has been hampered by cost and availability of equipment. A UK company proposes a flexible range of reactor systems with off the shelf designs, based on several years of development in the field and feedback from many customers. Now the value added from switching to continuous chemistry greatly outweighs the cost. Chemical research laboratories are sought for commercial agreements with technical assistance and adaptation to specific needs
- Commercial agreement with technical assistance
- Technical cooperation agreement
Continuous flow chemistry is a well-established technique when manufacturing large quantities of a given material. However, it is not yet established in the laboratory environment.
A UK company has many man-years of experience in developing continuous reactor systems. As more and more users have defined the features of choice in terms of mixing and heat transfer, an “off the shelf” system has emerged that is proven, robust and affordable.
Up to 4 reactors can be connected (see Picture 1) with excellent (and individually controlled) temperature and pressure capability. A preheat mixing station allows reactants to be brought to the desired temperature. A cooling and pressure control station allows regulation of the upstream pressure and cooling prior to depressurisation to avoid solvent boiling. The outlet stream can be collected as a final product or be used as an intermediate in a subsequent reaction.
The reactors can be configured to run batch chemistry in parallel. This can be used for instance to run identical reactions to measure the reproducibility of a developed process.
The control is flexible to support a statistically designed approach (DoE – Design of Experiment). Online analytical tools can be plugged into the system.
Not only can the reactor volume be adjusted but also the contacting patterns for various combinations of high and low concentrations of reactant.
A simpler tubular reactor design is also available for continuous flow chemistry, see Picture 2. Again the design is flexible, to accommodate a range of residence volumes.
In both systems, the materials used (stainless steel, superalloys) guarantee the parts to remain free of corrosion and contamination.
In addition to the current designs, bespoke systems can be produced with short lead times thanks to the long experience within the company. Training can be done in a day, either at the customer site or in the UK. Technical support is available globally.
Current and Potential Domain of Application:
Partner expertise sought:
- Type of partner sought:
- Specific area of activity of the partner: - Type of partner sought: industry and academia
- Specific area of activity of the partner: chemical research labs
- Task to be performed by the partner sought: integration of existing designs or together with the UK company, adaptation of the system to specific needs.
- Task to be performed by the partner sought:
Advantages & innovations:
The design of the flow reactor system is based on extensive secret know-how and feedback from a large number of customers.
• Mixed reactor design easily adapts to continuous or batch chemistry
• Suitable for liquid and gas-liquid chemistries
• Excellent temperature and pressure capability
• Accommodates on-line analysis tools
• Compact and easy to install
Listed under: Medicine and Health \ Chemistry & Chemical Engineering \ Biosciences and Health \ Drug Discovery and Development
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