Last updated: 05/04/2013
Closing date: 05/04/2014
A UK company has developed a continuous flow reactor for seamless reaction optimisation, synthesis and scale up. Already on the market the modular system offers improved mixing and heat transfer and enables reactions to be carried out at up to 260°C and pressures up to 1000 psi. Advantages include efficiency, higher yields, increased reaction selectivity, space savings, safety and future proofing at a sensible price. The company is seeking research and laboratory partners.
- Commercial agreement with technical assistance
- Technical cooperation agreement
Continuous flow chemistry is an emerging technology for drug discovery that has broad applicability in reaction optimisation and scale up. For example the potential to scale up continuous flow chemistries from mgs to the 100 of grams required to assess safety in man, without the need to modify the synthetic route can save both time and money. In comparison to conventional batch processes key advantages include:
improved mixing & heat transfer (which leads to excellent reproducibility)
easier scale-up, with less re-optimisation
less problems with unstable intermediates or highly exothermic reactions
It is also easier to add additional features such as on-line analysis and pressurization. However current commercial systems are very expensive and the lack of single commercially available instruments has previously hindered progress in this area.
The new fully integrated benchtop continuous flow reactor has been specifically designed to make flow chemistry available to all and at a sensible price. Already on the market the system provides synthetic and process chemists with the required choice of functionality in an integrated, rational system. It enables seamless reaction optimisation, synthesis and scale up from milligrams to hundreds of grams. Designed by a team of experienced flow chemists and engineers the modular system can easily be upgraded as the chemists knowledge and needs grow.
Current and Potential Domain of Application: The versatile equipment can be used for the synthesis of a wide range of chemicals and materials, in key markets such as:
Applications include Compound Library Generation, Process Development and Compound Synthesis. There continues to be huge interest in this novel flow reactor since market launch in late 2007.
Partner expertise sought:
- Type of partner sought: High activation energy chemistries that might previously have required a catalyst or the use of a microwave reactor are now potential candidates for continuous flow synthesis, with its attendant benefits - better reproducibility and scalability and fewer problems with unstable intermediates or unexpected exotherms.
The system uses Exchangeable Micro Reactor Technology, or EMRT. This is a compact, coiled reactor (patent pending) with excellent controllability that makes it possible to closely reproduce reaction conditions in different reaction volumes. Modular design makes it simple to interchange reactors with different volumes and materials stainless steel, PTFE or PEEK, and in future glass and various specialised materials. Depending on the reactor material, temperatures and pressures up to 200ΊC and 50 bar can be used.
- Specific area of activity of the partner: The UK Company is looking for synthetic and process chemical laboratories and research institutes with continuous flow synthesis needs (e.g. pharmaceutical, biotech, chemicals process development & production - & materials).
The UK Company will provide ongoing technical support, training and software upgrades etc. Because it is a new technique they believe ongoing information exchange will be a key element of any collaboration.
- Task to be performed by the partner sought:
Advantages & innovations:
Reactions can be carried out at up to 260°C and pressures up to 1000 psi to mimic microwave reactions without scale up issues. Other important features include:
Space Saving Compact footprint fits easily into fume cupboard
Safety Pressurised parts are protected and isolated. An active pressure monitoring system is standard
Time Saving Short set up & reaction times
Faster reactions - Solvent can be superheated to 260°C
Efficiency unattended operation. System equilibrates, runs reaction & cleans automatically
Future-proof optional modules compatible with the base system available
The main benefits over batch methods include higher yields, increased reaction selectivity, improved control of exothermic reactions, excellent reproducibility and faster reaction optimisation.
Listed under: Materials Technology \ Medicine and Health \ Chemistry & Chemical Engineering \ Biosciences and Health \ Drug Discovery and Development
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